Extracellular matrix receptors in branched organs

► Branching morphogenesis requires cell-extracellular matrix (ECM) interactions. ► ECM and ECM receptors are required for branched organ development. ► Laminins and fibronectin are the principal ECM required for branching. ► Laminin receptors are the major integrins. ► Dystroglycan plays a minor role in branched organ development.