Cross-talk between calcium and protein kinase A in the regulation of cell migration

► Ca2+ and PKA are pleiotropic cellular regulators of cell migration. ► There are numerous mechanisms through which Ca2+ and PKA can regulate each other. ► TRP channels and store-operated Ca2+ entry are newly and strongly implicated in migration. ► We present published and new, unpublished data connecting PKA to TRP channels and SOCE. ► We hypothesize that Ca2+/PKA cross-talk is an important regulatory axis for migration.