کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10929248 | 1093234 | 2013 | 9 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Membrane and actin dynamics interplay at lamellipodia leading edge
ترجمه فارسی عنوان
غشاء و دینامیک اکتین در لبه لاملیپودیا متضاد هستند
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
چکیده انگلیسی
The multimolecular WAVE regulatory (WRC) and Arp2/3 complexes are primarily responsible to generate pushing forces at migratory leading edges by promoting branch elongation of actin filaments. The architectural complexity of these units betrays the necessity to impose a tight control on their activity. This is exerted through temporally coordinated and coincident signals which limit the intensity and duration of this activity. In addition, interactions of the WRC and Arp2/3 complexes with membrane binding and surprisingly membrane trafficking proteins is also emerging, revealing the existence of an 'endocytic wiring system' that spatially restrict branched actin elongation for the execution of polarized functions during cell migration.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Cell Biology - Volume 25, Issue 5, October 2013, Pages 565-573
Journal: Current Opinion in Cell Biology - Volume 25, Issue 5, October 2013, Pages 565-573
نویسندگان
Sara Bisi, Andrea Disanza, Chiara Malinverno, Emanuela Frittoli, Andrea Palamidessi, Giorgio Scita,