کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10929327 1093239 2012 8 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Structure, function and regulation of spliceosomal RNA helicases
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Structure, function and regulation of spliceosomal RNA helicases
چکیده انگلیسی
Pre-mRNA splicing requires the activities of several ATPases from the DEAH-box, DEAD-box and Ski2-like helicase families to control conformational rearrangements within the spliceosome. Recent findings indicate that several spliceosomal helicases can act at multiple stages of the splicing reaction, and information on how those multiple actions are controlled are emerging. The recently solved crystal structure of the DEAH-box helicase Prp43 provides novel insights into the similarities and differences between the three helicase families. Here we discuss the potential family-specific mechanisms of spliceosomal RNA helicases and their regulation.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Cell Biology - Volume 24, Issue 3, June 2012, Pages 431-438
نویسندگان
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