کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10929401 1093252 2008 6 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
αvβ3 integrin and angiogenesis: a moody integrin in a changing environment
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
αvβ3 integrin and angiogenesis: a moody integrin in a changing environment
چکیده انگلیسی
In the adult, angiogenesis, the formation of new blood vessels from pre-existing vasculature contributes to the pathogenesis of many disorders including cancer. The role of adhesion molecules, especially integrins, in pathological angiogenesis has long been the subject of investigation, mostly because of their potential as anti-angiogenic targets. Recent studies have highlighted the complexities connected with understanding the roles of one particular integrin, αvβ3, in neovascularization. This integrin is notoriously promiscuous and its precise functions in angiogenesis are unclear. Here, I have firstly summarized some of the salient features of the roles played by αvβ3 during angiogenesis; secondly attempted to address the apparently conflicting issues surrounding this topic; and finally raised some questions that appear to be unanswered.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Current Opinion in Cell Biology - Volume 20, Issue 5, October 2008, Pages 514-519
نویسندگان
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