Re-evaluating the role of activin-βC in cancer biology

Covering a novel and previously unexplored function of activin-βC on cancer associated weight loss and muscle metabolism, this review suggests an imminent need to re-evaluate the function of activin-βC in biological systems and advances the understanding of how activin-βC antagonizes the activin signaling pathway. Thus, challenging activin biologists to consider the impact of activin-βC when interpreting their work.