کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10930069 | 1093377 | 2015 | 6 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders
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کلمات کلیدی
CNTFIFNγgp130ADAMTS5LIFRCISSCNTFRNeuropoietinLIFinterferon γ - اینترفرون γleukemia inhibitory factor - عامل مهارکننده لوکمیciliary neurotrophic factor - فاکتور نوروتروفیک ciliaryglycoprotein 130 - گلیکوپروتئین 130leukemia inhibitory factor receptor - گیرنده عامل مهار کننده لوکمیCiliary neurotrophic factor receptor - گیرنده فاکتور فاکتور نورودرمانی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders Cardiotrophin-like cytokine factor 1 (CLCF1) and neuropoietin (NP) signalling and their roles in development, adulthood, cancer and degenerative disorders](/preview/png/10930069.png)
چکیده انگلیسی
Mutations in cardiotrophin-like cytokine factor (CLCF1) and the related cytokine to which it binds, cytokine receptor-like factor 1 (CRLF1), are associated with Crisponi/cold induced sweating syndromes, and lead to early neonatal death in mice due to a suckling defect. These cytokines are members of the IL-6 superfamily, and form a range of composite cytokines that signal through gp130 bound either to the ciliary neurotrophic factor receptor (CNTFR) or a complex that involves the IL-27 p28 subunit. This review describes current knowledge of the signalling complexes formed by these cytokines, and explores their described and suggested roles in the neural, haematopoietic, skeletal, renal, immune and respiratory systems during development and adulthood, and in degenerative diseases and cancer.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Cytokine & Growth Factor Reviews - Volume 26, Issue 5, October 2015, Pages 517-522
Journal: Cytokine & Growth Factor Reviews - Volume 26, Issue 5, October 2015, Pages 517-522
نویسندگان
Natalie A. Sims,