کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10931200 1093621 2016 22 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Chx10 functions as a regulator of molecular pathways controlling the regional identity in the primordial retina
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Chx10 functions as a regulator of molecular pathways controlling the regional identity in the primordial retina
چکیده انگلیسی
The light-sensitive neural retina (NR) and the retinal pigmented epithelium (RPE) develop from a common primordium, the optic vesicle, raising the question of how they acquire and maintain distinct identities. Here, we demonstrate that sustained misexpression of the Chx10 homeobox gene in the presumptive RPE in chick suppresses accumulation of melanin pigments and promotes ectopic NR-like neural differentiation. This phenotypic change involved ectopic expression of NR transcription factor genes, Sox2, Six3, Rx1 and Optx2, which, when misexpressed, counteracted RPE development without upregulating Chx10. These results suggest that Chx10 can function as a cell autonomous regulator of the regional identity in the primordial retina, presumably through a downstream transcriptional cascade.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 413, Issue 1, 1 May 2016, Pages 104-111
نویسندگان
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