کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10931409 | 1093636 | 2015 | 32 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
SUN4 is essential for nuclear remodeling during mammalian spermiogenesis
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: SUN4 is essential for nuclear remodeling during mammalian spermiogenesis SUN4 is essential for nuclear remodeling during mammalian spermiogenesis](/preview/png/10931409.png)
چکیده انگلیسی
One of the more dramatic examples of cellular reorganization occurs during spermiogenesis in which a roughly spherical spermatid is transformed into a mature sperm cell. A highlight of this process involves nuclear remodeling whereby the round spermatid nucleus is sculpted into an elongated and polar structure. This transformation in nuclear architecture features chromatin condensation, changes in the composition and organization of the nuclear lamina and redistribution and elimination of nuclear pore complexes. The manchette, a cytoplasmic microtubule-based structure is thought to play a crucial role in the remodeling process. Here we show that SUN4, a spermatid nuclear membrane protein has an essential function in coupling the manchette to the nuclear periphery. In the absence of SUN4, manchette microtubules appear highly disorganized and the nucleus itself fails to elongate. Consequently, mice deficient in SUN4 display globozoospermia with associated infertility.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 407, Issue 2, 15 November 2015, Pages 321-330
Journal: Developmental Biology - Volume 407, Issue 2, 15 November 2015, Pages 321-330
نویسندگان
Alessandra Calvi, Arnette Shi Wei Wong, Graham Wright, Esther Sook Miin Wong, Tsui Han Loo, Colin L. Stewart, Brian Burke,