کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10931697 1093662 2015 12 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Elf5 and Ets2 maintain the mouse extraembryonic ectoderm in a dosage dependent synergistic manner
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Elf5 and Ets2 maintain the mouse extraembryonic ectoderm in a dosage dependent synergistic manner
چکیده انگلیسی
The ETS superfamily transcription factors Elf5 and Ets2 have both been implicated in the maintenance of the extraembryonic ectoderm (ExE) of the mouse embryo. While homozygous mutants of either gene result in various degrees of ExE tissue loss, heterozygotes are without phenotype. We show here that compound heterozygous mutants exhibit a phenotype intermediate to that of the more severe Elf5−/− and the milder Ets2−/− mutants. Functional redundancy is shown via commonalities in expression patterns, in target gene expression, and by partial rescue of Elf5−/− mutants through overexpressing Ets2 in an Elf5-like fashion. A model is presented suggesting the functional division of the ExE region into a proximal and distal domain based on gene expression patterns and the proximal to distal increasing sensitivity to threshold levels of combined Elf5 and Ets2 activity.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 397, Issue 1, 1 January 2015, Pages 77-88
نویسندگان
, , ,