کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10932029 | 1093684 | 2013 | 16 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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![عکس صفحه اول مقاله: Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner Sost and its paralog Sostdc1 coordinate digit number in a Gli3-dependent manner](/preview/png/10932029.png)
چکیده انگلیسی
WNT signaling is critical in most aspects of skeletal development and homeostasis, and antagonists of WNT signaling are emerging as key regulatory proteins with great promise as therapeutic agents for bone disorders. Here we show that Sost and its paralog Sostdc1 emerged through ancestral genome duplication and their expression patterns have diverged to delineate non-overlapping domains in most organ systems including musculoskeletal, cardiovascular, nervous, digestive, reproductive and respiratory. In the developing limb, Sost and Sostdc1 display dynamic expression patterns with Sost being restricted to the distal ectoderm and Sostdc1 to the proximal ectoderm and the mesenchyme. While Sostdc1â/â mice lack any obvious limb or skeletal defects, Sostâ/â mice recapitulate the hand defects described for Sclerosteosis patients. However, elevated WNT signaling in Sostâ/â; Sostdc1â/â mice causes misregulation of SHH signaling, ectopic activation of Sox9 in the digit 1 field and preaxial polydactyly in a Gli1- and Gli3-dependent manner. In addition, we show that the syndactyly documented in Sclerosteosis is present in both Sostâ/â and Sostâ/â; Sostdc1â/â mice, and is driven by misregulation of Fgf8 in the AER, a region lacking Sost and Sostdc1 expression. This study highlights the complexity of WNT signaling in skeletal biology and disease and emphasizes how redundant mechanism and non-cell autonomous effects can synergize to unveil new intricate phenotypes caused by elevated WNT signaling.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 383, Issue 1, 1 November 2013, Pages 90-105
Journal: Developmental Biology - Volume 383, Issue 1, 1 November 2013, Pages 90-105
نویسندگان
Nicole M. Collette, Cristal S. Yee, Deepa Murugesh, Aimy Sebastian, Leila Taher, Nicholas W. Gale, Aris N. Economides, Richard M. Harland, Gabriela G. Loots,