Differential response of epithelial stem cell populations in hair follicles to TGF-β signaling

► Isthmus displays abnormal proliferation/differentiation upon TGF-β signaling loss. ► Lrig1 expression in isthmus stem cells is decreased upon loss of TGF-β signaling. ► HF progenitors undergo premature activation and precocious apoptosis upon loss of TGF-β signaling. ► Lgr5 expression in cycling HFSCs is decreased upon loss of TGF-β signaling. ► Differential responses of adult stem cells in hair follicles to TGF-β signaling.