کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10932271 1093712 2012 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Engrailed cooperates directly with Extradenticle and Homothorax on a distinct class of homeodomain binding sites to repress sloppy paired
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Engrailed cooperates directly with Extradenticle and Homothorax on a distinct class of homeodomain binding sites to repress sloppy paired
چکیده انگلیسی
► Multiple slp CRMs are targets of repression by both Engrailed and Even-skipped. ► Despite similar individual binding specificities, they have distinct target sites. ► Engrailed binds with the Hox cofactors Exd and Hth to sites in two separate CRMs. ► Several essential target sites were localized and their functionalities compared. ► Affinity in vitro, by itself, poorly predicts functionality in vivo.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 366, Issue 2, 15 June 2012, Pages 382-392
نویسندگان
, , , , ,