Tenascin C regulates proliferation and differentiation processes during embryonic retinogenesis and modulates the de-differentiation capacity of Müller glia by influencing growth factor responsiveness and the extracellular matrix compartment

► Tnc exerts inhibitory influence on G2-phase cells of the retina. ► Tnc modulates growth factor responsiveness of retinal stem/progenitor cells. ► Tnc supports the de-differentiation ability of Müller glia. ► Expression of the DSD-1-chondroitin sulfate side chain is increased in Tnc-deficient retinas.