Crosstalk between Fgf and Wnt signaling in the zebrafish tailbud

► Time resolved analysis of Fgf and Wnt signaling in the zebrafish tailbud. ► Fgf and Wnt pathways are intertwined via protein phosphorylation. ► Fgf and Wnt pathways are also intertwined via transcriptional regulation. ► Fgf and Wnt have opposing effects on most transcriptionally co-regulated genes.