The role of Irf6 in tooth epithelial invagination

► Irf6 mutants show evagination of incisor tooth epithelium, rather than invagination. ► Evagination in Irf6 mutants phenocopies those seen in Ikkα mutants. ► No genetic interaction between Irf6 and Ikka in epithelial invagination. ► The Wnt pathway is normally suppressed by Ikkα/Irf6 in epithelial invagination. ► Ikkα/Irf6 regulates epithelial invagination via NF-κB-independent pathway.