The formation of an angiogenic astrocyte template is regulated by the neuroretina in a HIF-1-dependent manner

► In neonatal retinas, HIF-1α is most abundantly expressed in the neuroretina. ► Neuroretina-specific HIF-1α knockouts show decreased tip cell filopodia. ► Neuroretina-specific HIF-1α knockouts show a sparse astrocyte template. ► PDGF-A injection restores defects in neuroretina-specific HIF-1α knockouts.