EGFR, Wingless and JAK/STAT signaling cooperatively maintain Drosophila intestinal stem cells

► EGFR signaling is required for maintenance and division of fly intestinal stem cells. ► EGFR activation requires both paracrine Vn and possible autocrine Spi/Krn signals. ► EGFR,Wg and JAK/STAT signaling function together to maintain intestinal stem cells.