DSulfatase-1 fine-tunes Hedgehog patterning activity through a novel regulatory feedback loop

►DSulf1 is a regulator of Hedgehog signalling during wing development. ►DSulf1 is expressed both in Hh producing and receiving cells. ►DSulf1 positively regulates Hh signalling in the source of the morphogen. ►DSulf1 negatively regulates Hh signalling in its target field. ►Our data evidence a novel Hh regulatory feedback loop, involving DSulf1.