The sperm surface localization of the TRP-3/SPE-41 Ca2Â +-permeable channel depends on SPE-38 function in Caenorhabditis elegans

► SPE-38 regulates the localization of TRP-3/SPE-41 channel in sperm. ► SPE-38 physically interacts with TRP-3/SPE-41. ► Both N- and C-termini of SPE-38 are important for fertility. ► The calcium influx remain unperturbed in spe-38 mutant sperm.