SOHLH1 and SOHLH2 coordinate spermatogonial differentiation

► SOHLH1 and SOHLH2 physically interact in vivo and control spermatogenic pathways. ► SOHLH1 and SOHLH2 combined deficiency disturb more pathways than single deficiency. ► The deficiency of SOHLHs increased expression of genes for stem cell maintenance. ► SOHLHs regulate pathways in stemness suppression and spermatogonial differentiation.