The LIM adaptor protein LMO4 is an essential regulator of neural crest development

► The LIM adaptor protein, LMO4, is essential for NC development. ► Morpholino-mediated knockdown of LMO4 leads to loss of NC precursor formation. ► LMO4 induces Slug and Snail, but inhibits expression of other NC-GRN components. ► LMO4 binds Slug and Snail proteins and modulates their function.