Multiple functions of PBRM-1/Polybromo- and LET-526/Osa-containing chromatin remodeling complexes in C. elegans development

► Screen for abnormal asymmetric cell division revealed accessory components of SWI/SNF. ► Both LET-526 and PBRM-1 regulate the asymmetric expression of the psa-3 gene. ► PBRM-1 is required for gonad primordium formation. ► LET-526 is required for DTC production from the gonad primordium. ► The core but not accessory SWI/SNF components are required for early embryogenesis.