The PP1 phosphatase Flapwing regulates the activity of Merlin and Moesin in Drosophila

► Flapwing (Flw) a PP1 phosphatase alters Mer and Moe phosphorylation in Drosophila. ► Loss of Flw alters the sub-cellular localization and activity of Mer and Moe. ► Constitutively active/inactive Mer or Moe partially recapitulates loss of Flw activity. ► Flw co-regulates Mer and Moe activity.