A revised model of Xenopus dorsal midline development: Differential and separable requirements for Notch and Shh signaling

► Xenopus floor plate (FP) comprises 3 distinct populations: 1° MFP, 2° MFP, LFP. ► Different FP populations have different requirements for Notch and Shh signaling ► Notch and Shh signaling act in parallel to specify 2° MFP during neurulation. ► Notch signaling regulates notochord vs. hypochord choices during gastrulation.