Protogenin mediates cell adhesion for ingression and re-epithelialization of paraxial mesodermal cells

► Protogenin (PRTG) is expressed in paraxial mesodermal lineage in chick embryos. ► PRTG overexpression results in the formation of cell aggregates in vitro and in vivo. ► PRTG-knockdown impairs the ingression and formation of the somites. ► PRTG mediates cell adhesion to regulate cell rearrangements of paraxial mesoderm lineage.