Developmental regulation of MURF ubiquitin ligases and autophagy proteins nbr1, p62/SQSTM1 and LC3 during cardiac myofibril assembly and turnover

► MURF muscle ubiquitin ligases are developmentally regulated in mouse heart. ► MURF2 is the dominant cardiac MURF isogene expressed from mouse E8.5 onwards. ► MURF2 regulates microtubule dynamics in cardiac sarcomere assembly in vitro. ► MURF 2 and 3 show partial functional compensation in sarcomere assembly.