Sprouty1 and Sprouty2 limit both the size of the otic placode and hindbrain Wnt8a by antagonizing FGF signaling

► The otic placode is enlarged in Sprouty1, Sprouty2 compound mutants. ► This enlargement is due to the recruitment of cells into the otic domain. ► Sprouty1, 2 transcripts are present in tissues responsive to FGF signals. ► Wnt8a expression in the hindbrain is expanded in Sprouty1, 2 compound mutants. ► Sprouty1, 2 antagonize FGF10 induction of the otic placode and Wnt8a expression.