Loss of Sprouty2 partially rescues renal hypoplasia and stomach hypoganglionosis but not intestinal aganglionosis in Ret Y1062F mutant mice

►Spry2 deficiency partially rescued renal hypoplasia in Ret Y1062F mutant mice. ►Spry2 deficiency partially rescued stomach hypoganglionosis in Ret Y1062F mutant mice. ►Spry2 regulates downstream signaling mediated by the GDNF/RET pathway in vivo.