The mouse KRAB zinc-finger protein CHATO is required in embryonic-derived tissues to control yolk sac and placenta morphogenesis

►The yolk sac in chato mutants has bubble-like protrusions. ►chato disrupts allantoic extension, preventing chorioallantoic attachment. ►chato causes an expansion of the chorion and failure of the ectoplacental cavity to close. ►Zfp568 is required in embryonic-derived tissues, including extraembryonic mesoderm. ►Zfp568 controls the expression of factors required for morphogenesis of extraembryonic tissues.