Alcama mediates Edn1 signaling during zebrafish cartilage morphogenesis

►Endothelin regulates Alcama expression in endoderm. ►Alcama mediates endothelin signaling during zebrafish chondrogenesis. ►Endodermal Alcama regulates neural crest differentiation non-autonomously. ►Nadl1.1 on neural crest regulates cartilage development. ►Alcama functionally synergizes with Nadl1.1 to mediate endothelin signaling.