کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10933104 | 1093767 | 2010 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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![عکس صفحه اول مقاله: Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors Cv2, functioning as a pro-BMP factor via twisted gastrulation, is required for early development of nephron precursors](/preview/png/10933104.png)
چکیده انگلیسی
The fine-tuning of BMP signals is critical for many aspects of complex organogenesis. In this report, we show that the augmentation of BMP signaling by a BMP-binding secreted factor, Crossveinless2 (Cv2), is essential for the early embryonic development of mammalian nephrons. In the Cv2-null mouse, the number of cap condensates (clusters of nephron progenitors, which normally express Cv2) was decreased, and the condensate cells exhibited a reduced level of aggregation. In these Cv2-/- condensates, the level of phosphorylated Smad1 (pSmad1) was substantially lowered. The loss of a Bmp7 allele in the Cv2-/- mouse enhanced the cap condensate defects and further decreased the level of pSmad1 in this tissue. These observations indicated that Cv2 has a pro-BMP function in early nephrogenesis. Interestingly, the renal defects of the Cv2-/- mutant were totally suppressed by a null mutation of Twisted gastrulation (Tsg), which encodes another BMP-binding factor, showing that Cv2 exerts its pro-BMP nephrogenic function Tsg-dependently. By using an embryonic kidney cell line, we presented experimental evidence showing that Cv2 enhances pro-BMP activity of Tsg. These findings revealed the molecular hierarchy between extracellular modifiers that orchestrate local BMP signal peaks in the organogenetic microenvironment.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 337, Issue 2, 15 January 2010, Pages 405-414
Journal: Developmental Biology - Volume 337, Issue 2, 15 January 2010, Pages 405-414
نویسندگان
Makoto Ikeya, Kumi Fukushima, Masako Kawada, Sachiko Onishi, Yasuhide Furuta, Shigenobu Yonemura, Toshio Kitamura, Tetsuya Nosaka, Yoshiki Sasai,