کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10933166 | 1093772 | 2009 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Essential mesenchymal role of small GTPase Rac1 in interdigital programmed cell death during limb development
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Essential mesenchymal role of small GTPase Rac1 in interdigital programmed cell death during limb development Essential mesenchymal role of small GTPase Rac1 in interdigital programmed cell death during limb development](/preview/png/10933166.png)
چکیده انگلیسی
Developing vertebrate limbs are often utilized as a model for studying pattern formation and morphogenetic cell death. Herein, we report that conditional deletion of Rac1, a member of the Rho family of proteins, in mouse limb bud mesenchyme led to skeletal deformities in the autopod and soft tissue syndactyly, with the latter caused by a complete absence of interdigital programmed cell death. Furthermore, the lack of interdigital programmed cell death and associated syndactyly was related to down-regulated gene expression of Bmp2, Bmp7, Msx1, and Msx2, which are known to promote apoptosis in the interdigital mesenchyme. Our findings from Rac1 conditional mutants indicate crucial roles for Rac1 in limb bud morphogenesis, especially interdigital programmed cell death.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 335, Issue 2, 15 November 2009, Pages 396-406
Journal: Developmental Biology - Volume 335, Issue 2, 15 November 2009, Pages 396-406
نویسندگان
Dai Suzuki, Atsushi Yamada, Takanori Amano, Rika Yasuhara, Ayako Kimura, Mizuho Sakahara, Noriyuki Tsumaki, Shu Takeda, Masaru Tamura, Masanori Nakamura, Naoyuki Wada, Tsutomu Nohno, Toshihiko Shiroishi, Atsu Aiba, Ryutaro Kamijo,