کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10933563 1093804 2008 10 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Differential requirements of a mitotic acetyltransferase in somatic and germ line cells
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Differential requirements of a mitotic acetyltransferase in somatic and germ line cells
چکیده انگلیسی
During mitosis different types of cells can have differential requirements for chromosome segregation. We isolated two new alleles of the separation anxiety gene (san). san was previously described in both Drosophila and in humans to be required for centromeric sister chromatid cohesion (Hou et al., 2007; Williams et al., 2003). Our work confirms and expands the observation that san is required in vivo for normal mitosis of different types of somatic cells. In addition, we suggest that san is also important for the correct resolution of chromosomes, implying a more general function of this acetyltransferase. Surprisingly, during oogenesis we cannot detect mitotic defects in germ line cells mutant for san. We hypothesize the female germ line stem cells have differential requirements for mitotic sister chromatid cohesion.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 323, Issue 2, 15 November 2008, Pages 197-206
نویسندگان
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