کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10934083 | 1093879 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Dynamic developmental regulation of the large non-coding RNA associated with the mouse 7C imprinted chromosomal region
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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چکیده انگلیسی
We show here that LNCAT is developmentally regulated, with transcript variants being specifically expressed through neuronal differentiation in postmitotic neurons. We demonstrate that the LNCAT and Snurf-Snrpn transcripts are independent although they share common exons. We show an absence of expression of LNCAT through gametogenesis and in early embryo excluding a role of LNCAT in the imprint establishment. We also report a range of observations that challenges the widely accepted model of imprinted gene silencing of Ube3a. Although these last data do not completely exclude that the LNCAT variants including “Ube3a-ATS”exons could repress the paternal allele of Ube3a, they do allow us to propose an alternative and consistent model.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 286, Issue 2, 15 October 2005, Pages 587-600
Journal: Developmental Biology - Volume 286, Issue 2, 15 October 2005, Pages 587-600
نویسندگان
Elodie Le Meur, Françoise Watrin, Miguel Landers, Rachel Sturny, Marc Lalande, Françoise Muscatelli,