کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10934092 | 1093880 | 2005 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
xBtg-x regulates Wnt/β-Catenin signaling during early Xenopus development
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
In Xenopus, two signaling systems, maternal β-Catenin and Nodal-related, are required for induction of the Spemann organizer and establishment of the body plan. By screening cDNA macroarrays for genes activated by these two signaling pathways, we identified Xenopus xBtg-x, a novel member of the Btg/Tob gene family of antiproliferative proteins. We show that xBtg-x is expressed in the dorsal mesendoderm (Spemann organizer tissue) of gastrula stage embryos and that its expression is regulated by both β-Catenin and Nodal-related signals. Microinjection of synthetic xBtg-x mRNA into Xenopus embryos induced axis duplication and completely rescued the ventralizing effects of UV irradiation through the activation of the canonical Wnt/β-Catenin signaling pathway. Interestingly, xBtg-x stimulated β-Catenin-dependent transcription without affecting the stability of β-Catenin protein. These data suggest that xBtg-x is a novel component of the Wnt/β-Catenin signaling pathway regulating early embryonic patterning.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 283, Issue 1, 1 July 2005, Pages 17-28
Journal: Developmental Biology - Volume 283, Issue 1, 1 July 2005, Pages 17-28
نویسندگان
Oliver Wessely, James I. Kim, Uyen Tran, Luis Fuentealba, E.M. De Robertis,