کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10934121 | 1093881 | 2005 | 14 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Wnt signaling controls the timing of oligodendrocyte development in the spinal cord
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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![عکس صفحه اول مقاله: Wnt signaling controls the timing of oligodendrocyte development in the spinal cord Wnt signaling controls the timing of oligodendrocyte development in the spinal cord](/preview/png/10934121.png)
چکیده انگلیسی
During spinal cord development, oligodendrocytes are generated from a restricted region of the ventral ventricular zone and then spread out into the entire spinal cord. These events are controlled by graded inductive and repressive signals derived from a local organizing center. Sonic hedgehog was identified as an essential ventral factor for oligodendrocyte lineage specification, whereas the dorsal cue was less clear. In this study, Wnt proteins were identified as the dorsal factors that directly inhibit oligodendrocyte development. Wnt signaling through a canonical β-catenin pathway prevents its differentiation from progenitor to an immature state. Addition of rmFz-8/Fc, a Wnt antagonist, increased the number of immature oligodendrocytes in the spinal cord explant culture, demonstrating that endogenous Wnt signaling controls oligodendrocyte development.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 282, Issue 2, 15 June 2005, Pages 397-410
Journal: Developmental Biology - Volume 282, Issue 2, 15 June 2005, Pages 397-410
نویسندگان
Takeshi Shimizu, Tetsushi Kagawa, Tamaki Wada, Yuko Muroyama, Shinji Takada, Kazuhiro Ikenaka,