کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10934122 | 1093881 | 2005 | 11 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Slit/Robo signaling is necessary to confine early neural crest cells to the ventral migratory pathway in the trunk
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Slit/Robo signaling is necessary to confine early neural crest cells to the ventral migratory pathway in the trunk Slit/Robo signaling is necessary to confine early neural crest cells to the ventral migratory pathway in the trunk](/preview/png/10934122.png)
چکیده انگلیسی
Neural crest cells migrate along two discrete pathways within the trunk of developing embryos. In the chick, early migrating crest cells are confined to a ventral pathway medial to the dermamyotome while later cells migrate on a dorsal pathway lateral to the dermamyotome. Here we show that Slits are expressed in the dermamyotome, that early migrating crest cells express the Slit receptors Robo 1 and Robo 2, that Slit2 repels migrating crest cells in an in vitro assay, and that the misexpression of a dominant-negative Robo1 receptor induces a significant fraction of early crest cells to migrate ectopically in the dorso-lateral pathway. These findings suggest that Slits, most likely those expressed in the dermamyotome, help to confine the migration of early crest cells to the ventral pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 282, Issue 2, 15 June 2005, Pages 411-421
Journal: Developmental Biology - Volume 282, Issue 2, 15 June 2005, Pages 411-421
نویسندگان
Li Jia, Lan Cheng, Jonathan Raper,