کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10934122 1093881 2005 11 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Slit/Robo signaling is necessary to confine early neural crest cells to the ventral migratory pathway in the trunk
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Slit/Robo signaling is necessary to confine early neural crest cells to the ventral migratory pathway in the trunk
چکیده انگلیسی
Neural crest cells migrate along two discrete pathways within the trunk of developing embryos. In the chick, early migrating crest cells are confined to a ventral pathway medial to the dermamyotome while later cells migrate on a dorsal pathway lateral to the dermamyotome. Here we show that Slits are expressed in the dermamyotome, that early migrating crest cells express the Slit receptors Robo 1 and Robo 2, that Slit2 repels migrating crest cells in an in vitro assay, and that the misexpression of a dominant-negative Robo1 receptor induces a significant fraction of early crest cells to migrate ectopically in the dorso-lateral pathway. These findings suggest that Slits, most likely those expressed in the dermamyotome, help to confine the migration of early crest cells to the ventral pathway.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 282, Issue 2, 15 June 2005, Pages 411-421
نویسندگان
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