کد مقاله کد نشریه سال انتشار مقاله انگلیسی نسخه تمام متن
10934440 1093894 2005 5 صفحه PDF دانلود رایگان
عنوان انگلیسی مقاله ISI
Interpreting clone-mediated perturbations of morphogen profiles
موضوعات مرتبط
علوم زیستی و بیوفناوری بیوشیمی، ژنتیک و زیست شناسی مولکولی بیولوژی سلول
پیش نمایش صفحه اول مقاله
Interpreting clone-mediated perturbations of morphogen profiles
چکیده انگلیسی
Generating clones of mutated cells within a wild-type tissue is a powerful experimental paradigm for elucidating gene function. Recently, this approach was employed for identifying genes that shape morphogen profiles in the Drosophila wing-imaginal disc. Interpreting such experiments poses a theoretical challenge. We present a general framework that links specific features of the morphogen profile in the clone vicinity to three basic morphogen properties: diffusion, degradation, and binding to immobile elements. Our results provide rigorous criteria to examine existing data and can facilitate the design and interpretation of future clone experiments.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Developmental Biology - Volume 278, Issue 1, 1 February 2005, Pages 203-207
نویسندگان
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