A Paracoccidioides brasiliensis glycan shares serologic and functional properties with cryptococcal glucuronoxylomannan

► Cryptococcus neoformans and Paracoccidioides brasiliensis share proteins required for capsule formation. ► P. brasiliensis yeast cells react with antibodies raised to cryptococcal GXM. ► A mannose-rich P. brasiliensis glycan fraction reacted with antibodies to cryptococcal GXM. ► C. neoformans incorporated P. brasiliensis molecules to form capsule-like surface networks. ► The P. brasiliensis GXM-like glycan is anti-phagocytic.