Protein phosphatase Z modulates oxidative stress response in fungi

► The structure of Aspergillus nidulans PpzA has been conserved. ► PpzA is functionally competent in heterologous yeast cells. ► However, PpzA affects neither salt tolerance nor cell integrity in A. nidulans. ► Rather, it is involved in oxidative stress signaling. ► Maintenance of normal oxidative stress tolerance is a novel function of fungal PPZ enzymes.