Characterisation of the heat shock factor of the human thermodimorphic pathogen Paracoccidioides lutzii

► This post-transcriptome study identified and characterised the hsf gene of P. lutzii. ► P. lutziihsftrans-complements S. cerevisiae acting as a heat shock factor. ► Hsf specifically associates in vitro to putative binding sites found in the promoters of Drk1 and Ryp1. ► An in silico genome search for Hsf binding sites found candidates in promoters of genes from several different functional categories. ► Hsf may control a wide range of cell functions in dimorphic fungi in addition to the response against stress.