کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10939578 | 1095261 | 2010 | 15 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The Sko1 protein represses the yeast-to-hypha transition and regulates the oxidative stress response in Candida albicans
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: The Sko1 protein represses the yeast-to-hypha transition and regulates the oxidative stress response in Candida albicans The Sko1 protein represses the yeast-to-hypha transition and regulates the oxidative stress response in Candida albicans](/preview/png/10939578.png)
چکیده انگلیسی
Cells respond to environmental changes triggering adaptive responses which are, in part, mediated by a transcriptional response. These responses are complex and are dependent on different transcription factors. The present work reports the implication of the Sko1 protein in several processes relevant to the physiology of Candida albicans. First, Sko1 acts as transcriptional repressor of genes involved in pathogenesis and hyphal formation, which results in increased expression of the hyphal related genes ECE1 and HWP1 without significant changes in the virulence using a mouse model of systemic infection. Second Sko1 is involved in the response to oxidative stress and sko1 mutants increase the sensitivity of hog1 to the myelomonocytic cell line HL-60. Genome-wide transcriptional analysis after hydrogen peroxide treatment revealed that sko1 mutants were able to generate an adaptive response similar to wild type strains, although important differences were detected in the magnitude of the transcriptional response. Collectively, these results implicate Sko1 as an important mediator of the oxidative stress response in C. albicans.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fungal Genetics and Biology - Volume 47, Issue 7, July 2010, Pages 587-601
Journal: Fungal Genetics and Biology - Volume 47, Issue 7, July 2010, Pages 587-601
نویسندگان
Rebeca Alonso-Monge, Elvira Román, David M. Arana, Daniel Prieto, Verónica Urrialde, César Nombela, Jesús Pla,