کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10939592 | 1095268 | 2011 | 10 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
The pH regulatory factor Pac1 regulates Tri gene expression and trichothecene production in Fusarium graminearum
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موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
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چکیده انگلیسی
Fungi manage the adaptation to extra-cellular pH through the PacC transcription factor, a key component of the pH regulatory system. PacC regulates the production of various secondary metabolites in filamentous fungi. In the important cereal pathogen Fusarium graminearum, the production of trichothecene is induced only under acidic pH conditions. Here, we examined the role of the PacC homologue from F. graminearum, FgPac1, on the regulation of trichothecene production. An FgÎPac1 deletion mutant was constructed in F. graminearum which showed a reduced development under neutral and alkaline pH, increased sensitivity to H2O2 and an earlier Tri gene induction and toxin accumulation at acidic pH. A strain expressing the FgPac1c constitutively active form of Pac1 exhibited a strongly repressed Tri gene expression and reduced toxin accumulation at acidic pH. These results demonstrate that Pac1 negatively regulates Tri gene expression and toxin production in F. graminearum.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Fungal Genetics and Biology - Volume 48, Issue 3, March 2011, Pages 275-284
Journal: Fungal Genetics and Biology - Volume 48, Issue 3, March 2011, Pages 275-284
نویسندگان
Jawad Merhej, Florence Richard-Forget, Christian Barreau,