کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10940789 | 1095512 | 2016 | 5 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Generation of cancer-specific CD8+ CD69+ cells inhibits colon cancer growth
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کلمات کلیدی
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
![عکس صفحه اول مقاله: Generation of cancer-specific CD8+ CD69+ cells inhibits colon cancer growth Generation of cancer-specific CD8+ CD69+ cells inhibits colon cancer growth](/preview/png/10940789.png)
چکیده انگلیسی
The therapy of colon cancer (Cca) is poor currently. The abnormality of immune function is recognized in cancer-bearing hosts. This study aims to inhibit Cca growth with the in vivo induction of Cca-specific CD8+ CD69+ T cell polarization. In this study, a mouse tumor model was created with a mouse colon cancer (Cca) cell line. The Cca-bearing mice were immunized with Cca extracts and alum (using as an adjuvant). The CD8+ CD69+ cell polarization status was analyzed by flow cytometry and enzyme-linked immunosorbent assay. The results showed that a Cca antigen-specific CD8+ CD69+ cells were induced in the Cca-bearing mice. The Cca growth was efficiently inhibited by the Cca-specific CD8+ CD69+ cell response. The Cca-specific CD8+ CD69+ cells were detected in the Cca mass and spleen, which had the ability to induce Cca cell apoptosis. In conclusion, the Cca-specific CD8+ CD69+ cell polarization can be induced in Cca-bearing mice, which can efficiently inhibit the Cca growth.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunobiology - Volume 221, Issue 1, January 2016, Pages 1-5
Journal: Immunobiology - Volume 221, Issue 1, January 2016, Pages 1-5
نویسندگان
Bin Lan, Jian Zhang, Dong Lu, Wenqin Li,