کد مقاله | کد نشریه | سال انتشار | مقاله انگلیسی | نسخه تمام متن |
---|---|---|---|---|
10941095 | 1095594 | 2012 | 12 صفحه PDF | دانلود رایگان |
عنوان انگلیسی مقاله ISI
Complement activation as a biomarker for Alzheimer's disease
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کلمات کلیدی
ABCA7A2MACTC4bpAntichymotrypsin - آنتیکیموتریپسینApoe - آپوapolipoprotein E - آپولیپوپروتئین Einflammation - التهاب( توروم) Beta-amyloid - بتا آمیلوئیدAlzheimer's disease - بیماری آلزایمرBiomarker - بیومارکرcomplement component 3 - جزء مکمل 3complement component 4 - جزء مکمل 4complement component 5 - جزء مکمل 5Blood - خونGenetic risk factors - عوامل خطر ژنتیکیAs - مانندComplement - متممC4b-binding protein - پروتئین C4b اتصالPlasma - پلاسما
موضوعات مرتبط
علوم زیستی و بیوفناوری
بیوشیمی، ژنتیک و زیست شناسی مولکولی
بیولوژی سلول
پیش نمایش صفحه اول مقاله
چکیده انگلیسی
There is increasing evidence from genetic, immunohistochemical, proteomic and epidemiological studies as well as in model systems that complement activation has an important role in the pathogenesis of Alzheimer's disease (AD). The complement cascade is an essential element of the innate immune response. In the brain complement proteins are integral components of amyloid plaques and complement activation occurs at the earliest stage of the disease. The complement cascade has been implicated as a protective mechanism in the clearance of amyloid, and in a causal role through chronic activation of the inflammatory response. In this review we discuss the potential for complement activation to act as a biomarker for AD at several stages in the disease process. An accurate biomarker that has sufficient predictive, diagnostic and prognostic value would provide a significant opportunity to develop and test for effective novel therapies in the treatment of AD.
ناشر
Database: Elsevier - ScienceDirect (ساینس دایرکت)
Journal: Immunobiology - Volume 217, Issue 2, February 2012, Pages 204-215
Journal: Immunobiology - Volume 217, Issue 2, February 2012, Pages 204-215
نویسندگان
Mohammed Aiyaz, Michelle K. Lupton, Petroula Proitsi, John F. Powell, Simon Lovestone,