Neuropeptide Y improves myocardial perfusion and function in a swine model of hypercholesterolemia and chronic myocardial ischemia

► NPY3-36 can stimulate angiogenesis in the setting of metabolic syndrome. ► NPY3-36 can improve myocardial perfusion and function. ► NPY3-36 can upregulate angiogenic factors and downregulate anti-angiogenic factors.