Stimulation of the AT2 receptor reduced atherogenesis in ApoE−/−/AT1A−/− double knock out mice

► Atherogenesis was increased in ramipril treated ApoE−/−/AT1A−/− mice. ► PD123,319 increased plaque development in ApoE−/−/AT1A−/− mice. ► AT2 receptor confers atheroprotective effects when AT1 receptor action is inhibited. ► Relevant antiatherosclerotic role of the AT2 receptor in atherosclerotic mice.