Loss of fibulin-2 protects against progressive ventricular dysfunction after myocardial infarction

► Absence of fibulin-2 in mice improved survival after myocardial infarction (MI) [82]. ► Absence of fibulin-2 attenuated ECM remodeling and preserved LV function after MI [84]. ► Fibulin-2 modulated angiotensin II-induced TGF-β signaling in vitro [70]. ► Inhibition of fibulin-2 may be beneficial in preventing heart failure after MI [81].