Effects of DPP-4 inhibition on cardiac metabolism and function in mice

► DDP-4 inhibitors like sitagliptin are novel drugs in type 2 diabetes therapy. ► Sitagliptin improves glucose tolerance and reduces weight gain in db/db−/− mice. ► Sitagliptin reduces elevated cardiac fatty acid uptake and oxidation in db/db−/− mice. ► Sitagliptin prevents myocardial fibrosis. ► Sitagliptin reduces AGEs and oxidative stress in cardiomyocytes of db/db−/− mice.